PegLyte

    Therapeutic Class (Gastroenterology):

    Gastrointestinal Lavage Preparation and Laxative

    Form:

    Powder for Oral Solution USP

    Format:

    Bottle containing 280 g of powder.

    Ingredients:

    Medicinal Ingredients: Polyethylene Glycol 3350: 238.18g; Sodium Sulphate: 22.96g; Sodium Bicarbonate: 6.76g; Sodium Chloride 5.85g; Potassium Chloride 3.05g;. Non-medicinal Ingredients: Fruit flavours and Sodium Saccharin.

    Strength:

    Once reconstituted with 4 Liters of water, the solution contains: Polyethylene Glycol 3350: 17.8 mmol/L; Sodium: 126.0 mmol/L; Potassium: 10.2 mmol/L; Chloride: 35.3 mmol/L; Sulphate: 40.4 mmol/L; Bicarbonate: 20.1 mmol/L

    Format:

    Box of 4 sachets of 70 g of powder

    Ingredients:

    Medicinal Ingredients: Polyethylene Glycol 3350: 59.55g; Sodium Sulphate: 5.74g; Sodium Bicarbonate: 1.69g; Sodium Chloride: 1.46g; Potassium Chloride: 0.76g. Non-medicinal Ingredients: Fruit Flavours and Sodium Saccharin

    Strength:

    Once reconstituted with 1 Liter of water, the solution contains: Polyethylene Glycol 3350 17.8 mmol/L; Sodium 126.0 mmol/L; Potassium 10.2 mmol/L; Chloride 35.3 mmol/L; Sulphate 40.4 mmol/L; Bicarbonate 20.1 mmol/L

    Indications:

    For bowel cleansing prior to examination (e.g., colonoscopy) or surgical procedure requiring a clean colon. Also indicated for the treatment of constipation following consultation with a doctor.

    Directions for Use:

    Preparation:
    70 g sachets (to be reconstituted with 1 L of water):
    Dissolve the entire contents of one sachet in 1 L (32 ounces) of water and stir rapidly to dissolve. Repeat for the other 3 sachets, one at a time, as needed. No additional ingredients, e.g. flavouring, should be added to the solution. Keep refrigerated during treatment, for optimal storage and to improve the taste.
    280 g bottle (to be reconstituted with 4 L of water): :
    Add tap water to the fill line (total volume 4 L). Replace cap tightly and mix well until all ingredients have dissolved.
    No additional ingredients, e.g. flavouring, should be added to the solution. Keep refrigerated during treatment, for optimal storage and to improve the taste.

    Usual Adult Dose:
    Colon cleansing before examination:
    No solid food should be consumed during the 3-hour period before PegLyte consumption.
    The rate of administration is 240 mL (8 oz) every 10 minutes. Rapid drinking of each portion is preferred rather than drinking small amounts continuously.
    The first bowel movement should occur approximately 1 hour after the start of PegLyte administration. Administration of PegLyte should be continued until the watery stool is clear and free of solid matter. This normally requires the consumption of approximately 3 to 4 L, although more or less may be required in some patients. The unused portion should be discarded.
    Constipation:
    Drink 240 to 480 mL/day for a week or less or as recommended by your doctor. Do not take any type of laxatives for more than one week, unless your doctor has ordered a special schedule for you. Treatment for 2 to 4 days may be required to produce a bowel movement. If no bowel movement occurs in 4 days, contact your doctor.

    Contraindications:

    Do not take if you have any of the following conditions (ask your doctor if you are unsure):

    • Ileus (blockage in the bowel)
    • Gastric retention
    • Bowel perforation
    • Gastrointestinal obstruction
    • Toxic colitis (inflamed large bowel with damage to the intestinal wall)
    • Toxic megacolon (acute swelling of the large bowel)
    • Or if you are hypersensitive (allergic) to any ingredient in this formulation (See non-medicinal ingredients above).

    Warnings/Precautions:

    BEFORE you use PegLyte, talk to your doctor or pharmacist if:

    • You have taken any other medication within two hours of when you plan to start taking PegLyte (you may be removing this medication from your gastrointestinal tract by taking PegLyte)
    • You have a history of electrolyte imbalance (hyponatremia) or are using diuretics
    • You have ulcerative colitis or any other inflammatory bowel disease ( e.g. Crohn’s disease)
    • You are pregnant or nursing
    • You have difficulty swallowing or have a pronounced gag reflex or are prone to vomiting
    • You have any allergies to this drug or its ingredients.

    Talk to your doctor if you have kidney or heart problems or any tendency to regurgitate (bring up) food from your stomach into your esophagus or any tendency to accidentally inhale food or regurgitate food into the trachea (breathing tube to the lungs).

    Contact your doctor if the following occurs while taking PegLyte if you develop severe bloating, abdominal pain or distension. Do not take this medication if you have abdominal pain, nausea or vomiting. Contact your doctor if you experience these or any other unexpected symptoms.

    Storage:

    Store the unopened sachets and bottle at room temperature, between 15oC and 30oC. Once reconstituted, the solution should be used within 48 hours after mixing if stored at room temperature. If kept refrigerated (2°C-8°C), use within 30 days. Discard unused portion.

    Keep out of reach of children.

    PegLyte is a registered trademark of Pharmascience Inc.

    These products may not be suitable for everyone. Read the labels and follow the directions of use.
    For additional information, contact us at 1-888-550-6060 or by email at medinfo@pendopharm.com.

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